ZBrush →
Digital sculpting, modeling and painting for characters, creatures and detailed surfaces.
Sculpting & editing
3D material painting for creating and refining textures on existing models.
Substance 3D Painter focuses on materials and textures for existing meshes rather than replacing a geometry modeler. Layered painting and material workflows refine the surface after the shape is established.
Prepare the mesh, UVs and required baking information, create materials, then export textures for the target renderer or engine.
Game/film material artists and product-asset texturing.
Import mesh/UVs → bake and paint → inspect → export textures.